Epimedium side effects and benefits, safety, risk, danger, caution
epimedium sagittatum herb
January 2 2017

Epimedium side effects
This herb is mainly used in the USA as an aphrodisiac and to combat fatigue. We suggest too high an amount in order to avoid side effects which include insomnia. Later we discuss the adverse reactions in more detail.

buy Epimidium Sagittatum, formulated by a medical doctor
Buy Epimedium at Horny Goat Weed or to see more up to date research information.
Epimedium sagittatum is one of the most valued herbs in Chinese herbalism.  In China it is especially used for supporting healthy sexual activity – thus its name, Horny Goat Weed. Epimedium sagittatum 400 mg has epimedium extract (standardized to 10% flavonoids as icariin).

Epimedium sagittatum supplement

Epimedium side effects, safety, risk, danger
Epimedium, when used in high doses, has side effects of increased heart rate and insomnia and these are similar to Tribulus plant libido herb. There could be heart rhythm disturbances on very high dosages.

Epimedium herb study
Little research has been published in the Western medical literature regarding this plant. Our Chinese study investigated the therapeutic effect of epimedium sagittatum (ES) on 22 patients with chronic renal failure on hemodialysis. Twelve patients with hemodialysis were served as controls. ES had a sex enhancing effect and improved their quality of life.

Epimedium herb mechanism of action, how it works
The exact way that epimedium works remains unclear. Animal studies have shown that it may influence levels of neurotransmitters such as norepinephrine, serotonin, and dopamine and reduce cortisol levels. The leaves of epimedium sagittatum contain a variety of flavonoids, icariin, sterols and an alkaloid called magnaflorine. It’s quite possible epimedium sagittatum influences several aspects of human sexual biochemistry. Icariin is known to help with erectile function.

Epimedium study, PDE-5 inhibitor
Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.
Zhonghua Yi Xue Za Zhi. 2004. Xin ZC,. Peking University, Xicheng District, Beijing
To clarify the mechanism of the therapeutic action of icariin on erectile dysfunction. PDE5 was isolated from the human platelet and PDE4 from the rat liver tissue. The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated. Papaverine served as the control drug. Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities. Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED.

Leukemia treatment
Cytotoxic effects of Coptis chinensis and Epimedium sagittatum (horny goat weed) extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth.
Clin Exp Pharmacol Physiol. 2004.
The study was conducted to evaluate the cytotoxic effects of Coptis chinensis and Epimedium sagittatum (horny goat weed) extracts and their major constituents on hepatoma and leukaemia cells in vitro. icariin (the major compound of Epimedium Sagittatum) showed no inhibition of either the hepatoma or leukemia cell lines. The results of the present study suggest that the Coptis chinensis extract and its major constituents berberine and coptisine possess active antihepatoma and antileukemia activities.

Epimedium herb summary and review
Epimedium extract supplementation is, in fact, likely to make you horny. Most users will notice a mild to moderate effect on the third or fourth day of use.

Epimedium herb and impotence, erectile dysfunction in a male
Q. Does epimedium herb help with erectile dysfunction?
A. In some people, it can. It may take a few days for the full benefits to be noticed.